Industrial Chemicals – REACH | Recent projects and references

Experience gained in previous risk assessment of Existing Chemicals

Experience with new and existing chemicals has been gained in over 20 years of experience of contract research and consulting on environmental and toxicological properties, in Risk Assessments (ESR), as well as in the compilation of IUCLID data sets and registration dossiers (REACH) on high production volume chemicals.

Metals Risk Assessments under the ESR regulation

In the period 1996-2003, EBRC was appointed as principal industry co-ordinator with overall responsibility for the human health section of the RAR on Zinc and Zinc compounds (Rapporteur Member State: NL). In this context, EBRC organised the collection and evaluation of occupational exposure data for four of the six lead companies, and their major downstream user industries, including inhalation and dermal exposure monitoring programmes. In addition, EBRC was contracted with collating environmental emissions inventories for production and downstream uses of various zinc compounds.

In addition, EBRC has provided support to the Nickel and Antimony industry in their EU ESR risk assessments.

Following up on this, EBRC continued to be involved in responsible functions for the Voluntary Risk Assessments on Lead and Lead compounds, and Copper and Copper compounds:

  • EBRC (Dr. Battersby) was appointed to the Scientific Review Panel of the Voluntary Risk Assessment on Copper and its inorganic compounds, conducted in the period 2004-2006
  • For Lead and 13 of its inorganic compounds, EBRC was co-author (together with ILZRO, NC, USA) of the HH section of the Voluntary Risk Assessment initiated by the European Lead industry in the period 2004-2006.
  • In these functions, EBRC also represented both industries also at TC NES meetings for the discussion with EU Member States.

Other EU risk assessment related activities

EBRC has also actively provided consulting activities for the European Flame Retardants Industry Associations, as well as the antimony industry in their EU RAR procedure for diantimony trioxide (ATO), a FR synergist.

EBRC has been appointed on several occasions to represent the Zinc, Cadmium, Copper and Lead industries (among others) as principal industry representative at the meetings of the EU TC C&L committee.

German National Existing Chemical Review Programme

As early as the late 1980s, Germany embarked on it’s own existing chemicals review programme, setting up their "BUA" system. In this context, EBRC was involved in the compilation of over 60 complete IUCLID data sets, including running the complete profile of extensive literature searches, acquiring and evaluating primary literature, and entering and validating the data in IUCLID format. In addition, several of these compounds were selected for detailed review, for which EBRC staff acted as principal authors.

Comprehensive reports were compiled for the German Advisory Committee on Existing Chemicals ("BUA") on the following high production volume chemical substances:

  • Dipropylene glycol (CAS-No.: 110-98-5)
  • Propylene glycol (CAS-No.: 57-55-6)
  • Dipropylene glycol methylether (CAS-No.: 34590-94-8)
  • Propylene glycol methylether (CAS-No.: 1320-67-8)
  • Dipropylenglykolmethylether (CAS-No: 34590-94-8)
  • Diisobutylphthalate (CAS-No.: 84-69-5)
  • Fatty alkyl sulphates (CAS-Non.: 151-21-3, 139-96-8, 68130-43-8)

More than 60 comprehensive IUCLID data sets were compiled for high production volume chemicals, as examplarily given below:

  • Nitrobenzol (CAS-No.: 98-95-3)
  • o-Chloranilin (CAS-No.: 95-51-2)
  • m-Chloranilin (CAS-No.: 108-42-9)
  • m-Phenylendiamin (CAS-No.: 108-45-2)
  • 2,4-Toluylendiamin (CAS-No.: 95-80-7)
  • Calciumhydroxid (CAS-No.: 1305-62-0)
  • Propylenglykol (CAS-No.: 57-55-6)
  • Dipropylenglykolmethylether (CAS-No.: 34590-94-8)
  • Propylenglykolmethylether (CAS-No.: 1320-67-8)
  • Octadecansäure (CAS-No.: 57-11-4)
  • Docosensäure (CAS-No.: 112-86-7)
  • Decandisäure, di-butylester (CAS-No.: 109-43-3)
  • Dodecanamid, N-(2-hydroxypropyl) (CAS-No.: 142-54-1)
  • Decandisäure, di-ethylhexylester (CAS-No.: 122-62-3)
  • Hexanedisäure, di-octylester+Isom. (CAS-No.: 123-79-5)
  • Decyloxiran (CAS-No.: 2855-19-8)
  • Methylcyclohexanol (CAS-No.: 25639-42-3)
  • Dimethylcyclohexylphthalat (CAS-No.: 27987-25-3)
  • Docosansäure, hexadecylester (CAS-No.: 42233-11-4)
  • Octadecansäure, 9,10-dihydroxy, Amm.-Salz (CAS-No.: 84753-04-8)
  • Dimethylsuccinat (CAS-No.: 106-65-0)
  • Aluminiumchlorid, bas. (CAS-No.: 1327-41-9)
  • Calcium bis-(dihydrogenorthophosphat) (CAS-No.: 7758-23-8)
  • Na Laurylsulfat (SDS) (CAS-No.: 151-21-3)
  • Schwefelsäure, monododecylester, TEA-Salz (CAS-No.: 130-96-8)
  • Schwefelsäure, mono-C8-18-Alkylester, Na-Salze
  • (CAS-Non. 681043-8, 85586-07-8, 73296-89-6, 68955-20-4, 68955-19-1)
  • p-Nitrobenzoesäure (CAS-No.: 62-23-7)
  • Glykolsäure (CAS-No.: 79-14-1)
  • 3-Methyl-1-phenylpyrazolon (CAS-No.: 89-25-8)
  • Phenothiazin (CAS-No.: 92-84-2)
  • 2,4-Dinitroanilin (CAS-No.: 97-02-9)
  • Distearylamin (CAS-No.: 112-99-2)
  • Dimethyloctadecylamin (CAS-No.: 124-28-7)
  • Acetic acid, cyano-, ethyl ester (CAS-No.: 105-56-6)
  • Hexane, 1,6-diisocyanatotrimethyl- (CAS-No.: 28679-16-5)
  • 1,2-Benzenedicarboxylic acid, mixed decyl and lauryl and
  • myristyl diesters (CAS-No. 90193-92-3)
  • Fatty acids, C14-18, 2-ethylhexyl ester (CAS-No.: 91031-47-9)